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Role of α7-Nicotinic Acetylcholine Receptor in Normal and Cancer Stem Cells

[ Vol. 13 , Issue. 5 ]

Author(s):

Waka Lin, Naoya Hirata and Yuko Sekino and Yasunari Kanda   Pages 656 - 665 ( 10 )

Abstract:


The α7-nicotinic acetylcholine receptor (α7-nAChR) is widely known as a neurotransmitter receptor in nervous systems. α7-nAChR is also present in a variety of non-neuronal tissues, where it has been implicated in the regulation of essential cellular functions including proliferation, survival, differentiation and communication. We have recently found in breast cancer that α7-nAChR is involved in the proliferation of cancer stem cells, which constitute a minor subpopulation responsible for tumor development and metastasis. Since growing evidence suggests that α7-nAChR is present not only in mature tissues and organs but also in undifferentiated stem cells and progenitor cells, α7-nAChR emerges as a key mediator in the regulation of self-renewal and differentiation. We provide here an overview of the recent works on the expression and function of α7-nAChR in normal and cancer stem cells, and their relevance to disease-related cellular dysfunction. Understanding the role of α7-nAChR in stem cells would be of great interest for its application potential in drug discovery and in regenerative medicine.

Keywords:

α7-Nicotinic Acetylcholine Receptors, breast cancer, cancer stem cell, nicotine, stem cells, neurotransmitter, HSC, protein kinase C, chemotherapies, cholinergic system

Affiliation:

1-18-1, Kamiyoga, Setagayaku 158-8501, Japan.



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