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CD93: Recent Advances and Implications in Disease

[ Vol. 13 , Issue. 3 ]

Author(s):

Mallary C. Greenlee-Wacker, Manuel D. Galvan and Suzanne S. Bohlson   Pages 411 - 420 ( 10 )

Abstract:


While it has been known for some time that CD93 regulates several processes involved in innate immunity and inflammation including phagocytosis and adhesion, the function of CD93 in disease progression is only now being elucidated. Recent in vivo studies in mice, and genome wide studies in mice and humans, have provided clues about its molecular function. Following a comprehensive review of CD93 expression patterns, this review will focus on recent findings over the last three years that address the putative function of CD93 in inflammation and innate immunity.

Keywords:

CD93, inflammation, innate immunity, Group XIV, adhesion, AA4.1, MMP cleavage site, microarray studies, ischemia, cancer

Affiliation:

Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.



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