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Ceramide Kinase and the Ceramide-1-Phosphate/cPLA2α Interaction as a Therapeutic Target

[ Vol. 9 , Issue. 8 ]

Author(s):

Nadia F. Lamour and Charles E. Chalfant   Pages 674 - 682 ( 9 )

Abstract:


Ceramide kinase (CERK) was discovered more than a decade ago. Since then, numerous reports have been published demonstrating a role for CERK in various signal transduction pathways involved in inflammation, immunity or cancer. In this review, the biosynthesis of ceramide-1-phosphate (C1P) and the various roles of CERK and C1P in biological mechanisms will be overviewed. We will focus on the role of C1P in eicosanoid synthesis, more specifically, in the activation and translocation of cPLA2α. Furthermore, the possible therapeutic relevance of inhibitors of these mechanisms is discussed.

Keywords:

family transferase, biosynthesis, Ceramide Kinase, Ceramide-1-Phosphate/cPLA2α, Therapeutic Target, biological mechanisms, eicosanoid synthesis, calcium mobilization

Affiliation:

Department of Biochemistry and Molecular Biology, Room 2-016, Sanger Hall, Virginia Commonwealth University-School of Medicine, 1101 East Marshall Street, P.O. Box 980614, Richmond, VA 23298-0614, USA.



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