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The Host Complement System and Arbovirus Pathogenesis

[ Vol. 9 , Issue. 2 ]


M. T. Heise and T. E. Morrison   Pages 165 - 172 ( 8 )


Arthropod-borne viruses (arboviruses) are a significant cause of human diseases worldwide. Interactions between these viruses and the innate immune system play a major role in determining the outcome of disease. The complement system is particularly important in this process as activation of complement can contribute to both host defense as well as injury to host tissues. This review focuses on the increasing evidence that the complement system plays key roles in both protective and pathologic outcomes of arbovirus infection.


Arbovirus, viral pathogenesis, alphavirus, flavivirus, complement


Carolina Vaccine Institute, University of North Carolina at Chapel Hill, 9th Floor Burnett-Womack, CB ᱼ, Chapel Hill, NC 27599, USA.

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