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Lipases as Modulators of Atherosclerosis in Murine Models

[ Vol. 8 , Issue. 12 ]


Robert J. Brown and Daniel J. Rader   Pages 1307 - 1319 ( 13 )


Lipoprotein lipase, hepatic lipase, and endothelial lipase are sn-1 lipases that play important roles in the metabolism of plasma lipoproteins. In vitro and in vivo studies suggest that these lipases exhibit both pro- and antiatherogenic properties, which are dependent primarily on their tissue localization. The following chapter reviews the physiology of these lipases, and the consequences of the loss or gain of function for each lipase in modulating atherosclerosis, with emphasis on murine models.


Lipase, lipoprotein, aortic lesion, coronary artery disease, atherosclerosis, transgenic mouse, knockout mouse


Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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