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Use of Mouse Models to Evaluate Roles of Nuclear Receptors and their Ligands in the Pathogenesis and Treatment of Atherosclerosis

[ Vol. 8 , Issue. 12 ]

Author(s):

A. C. Li and C. K. Glass   Pages 1273 - 1287 ( 15 )

Abstract:


Nuclear receptors form a large family of ligand-dependent transcription factors that regulate diverse aspects of development and homeostasis. Several of these receptors have been demonstrated to play important roles in controlling biological processes that influence the development and clinical consequences of atherosclerosis. Because nuclear receptors are regulated by small molecules, they are potential targets for anti-atherogenic drugs. In this chapter, we review the use of mouse models to evaluate roles of nuclear receptors and their ligands in the pathogenesis and treatment of atherosclerosis.

Keywords:

retinoid X receptors, cholesterol ester transport protein, PPAR Alpha, ABCA1 expression, VLDL level

Affiliation:

Department of Medicine,UC San Diego and Department of Cellular and Molecular Medicine, UC San Diego, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.



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