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Oxidative Stress as a Regulator of Murine Atherosclerosis

[ Vol. 8 , Issue. 12 ]


Tzung Hsiai and Judith A. Berliner   Pages 1222 - 1229 ( 8 )


Altered cellular production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) is a ubiquitous feature of human disease. Vascular oxidative stress is a unifying area of research in atherosclerosis and aging. While elevated levels of ROS, especially oxygen radicals (O2 -ยท) and hydrogen peroxide (H2O2), induce cellular apoptosis, low levels play an important role in cell signaling [1,2]. Reactive species from a variety of sources further play an important role in plaque disruption partly through lipid oxidation, low-density lipoprotein oxidation nitration, and signaling [3- 6].


NADPH Oxidase, dihydroethidium, superoxide dismutase, Lipoxygenase, xanthine oxidase


Professor in Residence of Medicine/Cardiology, and Pathology, Office: 13-229 CHS, USA.

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