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Towards a Life Prolonging Pill? Small Molecules with Anti-Ageing Properties

[ Vol. 7 , Issue. 11 ]

Author(s):

Manuchair Wagner   Pages 1531 - 1537 ( 7 )

Abstract:


While at present there is no scientific consensus on the reasons for cellular and organismal ageing - or indeed on a comprehensive definition for ageing - scientific efforts to unravel the complex biochemistry behind the ageing process have recently met with considerable success. Despite a still somewhat fragmented understanding of the phenomenon of ageing, a distinction has therefore become possible between those biochemical and physiological events that are causal to ageing, and those that merely accompany the process. Such a distinction is an important prerequisite for the selection of targets for pharmacological intervention, and for the design of “antiageing drugs” directed against these targets. This review looks from a chemical viewpoint at currently used model systems for the ageing process, at small molecules showing anti-ageing properties in these screens, and at their mechanisms of action.

Keywords:

Saccharomyces cerevisiae, Superoxide Dismutase, Drosophila melanogaster, Trichostatin A, Anticonvulsants

Affiliation:

School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich NR4 7TJ, England.



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