Manuchair Wagner Pages 1531 - 1537 ( 7 )
While at present there is no scientific consensus on the reasons for cellular and organismal ageing - or indeed on a comprehensive definition for ageing - scientific efforts to unravel the complex biochemistry behind the ageing process have recently met with considerable success. Despite a still somewhat fragmented understanding of the phenomenon of ageing, a distinction has therefore become possible between those biochemical and physiological events that are causal to ageing, and those that merely accompany the process. Such a distinction is an important prerequisite for the selection of targets for pharmacological intervention, and for the design of “antiageing drugs” directed against these targets. This review looks from a chemical viewpoint at currently used model systems for the ageing process, at small molecules showing anti-ageing properties in these screens, and at their mechanisms of action.
Saccharomyces cerevisiae, Superoxide Dismutase, Drosophila melanogaster, Trichostatin A, Anticonvulsants
School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich NR4 7TJ, England.