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Clinical Aspects of Natural Anti-Angiogenic Drugs

[ Vol. 7 , Issue. 3 ]

Author(s):

C. P. Neal, D. P. Berry, H. Doucas, M. M. Manson, W. Steward and G. Garcea   Pages 371 - 383 ( 13 )

Abstract:


Natural products represent a rich resource for drug discovery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived from varied species of plant, animal and micro-organism. Over a dozen of these agents have now entered clinical trial. This review discusses evidence for the efficacy of this drug class and key issues in the translation of pre-clinical results into the development of efficacious drugs for clinical use.

Keywords:

Angiogenesis, cancer, therapeutics, proliferation, natural, endogenous

Affiliation:

Department of Cancer Studiesand Molecular Medicine, 5th floor, Robert Kilpatrick Clinical SciencesBuilding, Leicester Royal Infirmary, Leicester, LE2 7LX, UK.



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