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Article Details


Antimitotic Agents of Natural Origin

[ Vol. 7 , Issue. 3 ]

Author(s):

Advait Nagle, Wooyoung Hur and Nathanael S. Gray   Pages 305 - 326 ( 22 )

Abstract:


Antimitotic agents have been the most successful pharmacological agents for the treatment of cancer. The term "antimitotic agent" has traditionally been synonymous with tubulin-targeting compounds, but as a consequence of the large number of new compounds and mechanisms that have been identified recently, a much broader definition is currently needed. This review attempts to provide a broad overview of compounds and their cognate protein targets which result in a block in mitosis. Focus has been placed on agents that act directly on the mitotic machinery rather than on targets further upstream such as growth factor receptors.

Keywords:

Microtubules, Paclitaxel, Epothilone A, malignant glioma cell lines, tubulin interacting agents, Vinca Alkaloids

Affiliation:

Genomics Institute of theNovartis Research Foundation, 10675 John J. Hopkins Drive, San Diego,CA 92121, USA.



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