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An Updated Review for the Diabetic Wound Healing Systems

Author(s):

Mehmet Evren Okur, Ece Özcan Bülbül, Gökçe Mutlu, Kalliopi Eleftherıadou, Ioannis D. Karantas, Neslihan Üstündağ Okur* and Panoraia I. Sıafaka*   Pages 1 - 27 ( 27 )

Abstract:


Background & Objective: Diabetes is a global health problem that has resulted in millions of deaths; one of the most common diabetes complications is that wounds of diabetic patients tend to heal more slowly or may not heal at all, resulting in undesirable outcomes. Diabetic wounds, if become chronic and infected, could provoke lower extremities amputation, sepsis, and even death. Hence, early detection, careful examination, debridement, cleaning, and prevention or controlling the infection of diabetic wounds are important factors for the successful outcome of the case. Over the years, various promising wound dressings incorporating antimicrobial molecules, growth factors, and wound healing agents have been developed, targeting diabetic wounds. Nonetheless, the choice of dressing is mainly based on the experience of each clinician.

Summary: This review summarizes the main points of diabetes complications, diabetic wounds, and infections. Further, an overview of the current drug delivery systems for topical wound delivery of various active ingredients has been performed. This update could be helpful for scientists and especially clinicians who desire to plan and work with new strategies for the healing of diabetic wounds.

Keywords:

Diabetic Wounds, Antimicrobials, Growth Factors, Scaffolds, Natural compounds, Wound healing.

Affiliation:

Department of Pharmacology, Faculty of Pharmacy, University of Health Sciences, Istanbul, Department of Pharmaceutical Technology, Faculty of Pharmacy, Istinye University, Istanbul, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Nicosia General Hospital, Nicosia, Cyprus; fKES College, Nicosia, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul, KES College, Nicosia



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