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Mesenchymal Stem Cells and Cancer Stem Cells: An Overview of Tumor- Mesenchymal Stem Cell Interaction for Therapeutic Interventions

Author(s):

Soheila Montazersaheb, Ezzatollah Fathi, Ayoub Mamandi, Raheleh Farahzadi* and Hamid Reza Heidari   Pages 1 - 12 ( 12 )

Abstract:


Tumors are made up of different types of cancer cells that contribute to tumor heterogeneity. Among these cells, cancer stem cells (CSCs) have a significant role in the onset of cancer and development. Like other stem cells, CSCs are characterized by the capacity for differentiation and self-renewal. A specific population of CSCs is constituted by mesenchymal stem cells (MSCs) that differentiate into mesoderm-specific cells. The pro-or anti-tumorigenic potential of MSCs on the proliferation and development of tumor cells has been reported as contradictory results. Also, tumor progression is specified by the corresponding tumor cells like the tumor microenvironment. The tumor microenvironment consists of a network of reciprocal cell types such as endothelial cells, immune cells, MSCs, and fibroblasts as well as growth factors, chemokines, and cytokines. In this review, recent findings related to the tumor microenvironment and associated cell populations, homing of MSCs to tumor sites, and interaction of MSCs with tumor cells will be discussed.

Keywords:

Mesenchymal stem cells, cancer stem cells, tumor microenvironment, tumor cells, homing of mesenchymal stem cells, regenerative medicine, therapeutic interventions.

Affiliation:

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz



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