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A Review on Anti-urease Potential of Coumarins

Author(s):

Humna Asghar*, Hafsa Asghar and Tanzeela Asghar   Pages 1 - 18 ( 18 )

Abstract:


Coumarins, a heterocyclic benzo-α-pyrones and naturally occurring ring structure that possess significant pharmacological properties, has attracted the attention of researchers and medicinal chemists to reveal the suitability of both natural and synthetic coumarins as drugs. Many compounds have been synthesized utilizing the basic coumarin structure. The diverse synthetic methods resulted in synthesis of important coumarin derivatives that offers wide range of biological properties as antimicrobial, anticancer, anti-inflammatory, antioxidant, antidiabetic and antidepressant that makes them potential drug candidate. With particular interest in ulcer coumarins have shown potential inhibition against urease enzyme. In recent years scientists have emphasized anti-urease activity of coumarins due to their low toxicity. The aim of this review is to compile data from recent research about anti-urease activities of coumarins and structure activity relationship studies of coumarin ring structure. Investigation of different structural substitution in coumarin ring may help researchers to design new compounds with strong and effective anti-urease abilities.

Keywords:

synthetic coumarins, natural coumarins, drug discovery, jack bean urease, H. pylori, SAR

Affiliation:

Department of Biochemistry and Biotechnology, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur, Department of Physics, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur, Shiekh Zayed Medical College, Rahim Yar Khan



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