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The Role of Non-coding Genome in Cancer-associated Fibroblasts; Stateof- the-Art and Perspectives in Cancer Targeted Therapy

[ Vol. 22 , Issue. 13 ]


Arezoo G. Shabgah, Hamed Mohammadi, Pouya Goleij, Mahdiyeh Hedayati-Moghadam, Arash Salmaninejad and Jamshid G. Navashenaq*   Pages 1524 - 1535 ( 12 )


Cancer-associated fibroblasts (CAFs) are senescent fibroblasts in tumor nest, which trigger a signaling center to remodel a desmoplastic tumor niche. CAF’s functions in cancer are closely similar to myofibroblasts during the wound healing process. They can produce cytokines, enzymes, and protein- or RNA-containing exosomes to alter the function of surrounding cells. Non-- coding RNAs, including microRNAs and long non-coding RNAs, modulate pathologic mechanisms in cancer. Dysregulation of these RNAs influences the formation and function of CAFs. Furthermore, it has been demonstrated that CAFs, by releasing non-coding RNAs-containing exosomes, affect the tumor cells’ behavior. CAFs also secrete mediators such as chemokines to alter the expression of non-coding RNAs in the tumor microenvironment. This study aimed to discuss the role of non-coding RNAs in CAF development in cancer. Additionally, we have shed light on the therapeutic approaches to develop the strategies based on the alteration of non-coding RNAs in cancer.


Non-coding RNA, miRNA, lncRNA, cancer, cancer-associated fibroblasts, fibroblasts.


Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Department of Genetics, Faculty of Biology, Sana Institute of Higher Education, Sari, Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Department of Medical Genetics, Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam

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