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Recent Progress on Apoptotic Activity of Triazoles

[ Vol. 22 , Issue. 16 ]

Author(s):

P. Çıkla-Süzgün and Ş. G. Küçükgüzel*   Pages 1844 - 1900 ( 57 )

Abstract:


Apoptosis is often called programmed cell death and is defined as a self-directed cell de-struction process. It is different from necrosis due to the activation of caspases during this process. Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis; all cytotox-ic drugs and radiation therapy programs initiate apoptosis in tumor cells. Today, studies show that heterocyclic compounds that contain triazole functionality have anticancer activities; triazoles are 5-membered rings, which contain two carbon and three nitrogen atoms. Therefore, many researchers have synthesized these small active compounds as target structures and evaluated their apoptotic ac-tivities. The present review describes recent medicinal aspects of triazoles as anticancer agents that have been reported during the past few years. We hope that the bioactivity of triazole derivatives will be beneficial for the rational design of a new generation of small molecule drugs.

Keywords:

Apoptosis, triazole, cancer, caspase-8, caspase-3, Bcl-2, cytochrome C.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Başıbüyük, 34854, Istanbul, Vocational School of Health Services, Fenerbahçe University, Ataşehir, 34758, Istanbul



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