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Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfunction

[ Vol. 22 , Issue. 14 ]

Author(s):

Hayrettin Ozan Gulcan and Ilkay E. Orhan*   Pages 1618 - 1628 ( 11 )

Abstract:


Flavonoids are chromene analogues abundantly found in plants. It has always been of interest to discover natural flavonoid structures, since living things, including humans, are routinely exposed to these compounds through many dietaries. So far, numerous studies have been conducted on flavonoids with diverse biological actions. The activity results obtained, particularly regarding the effects of flavonoids on various validated and non-validated targets of Alzheimer’s Disease (AD), make these compounds promising agents either to be directly employed in clinical trials or to be utilized as important scaffolds for flavonoid-based drug design studies. Although there are many review articles on the treatment and protective effects of flavonoids on AD, within this review, the effects of flavonoids on mitochondrial dysfunction developing throughout AD have been presented concomitant to their structural organization.

Keywords:

Flavonoids, Alzheimer`s disease, mitochondrial dysfunction, reactive oxygen species, amyloid beta, chromene analogues.

Affiliation:

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, T.R. North Cyprus, via Mersin 10, Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara



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