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Implications of microRNAs in the Pathogenesis of Atherosclerosis and Prospects for Therapy

[ Vol. 22 , Issue. 15 ]

Author(s):

Armita M. Gorabi, Mohsen Ghanbari, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*   Pages 1738 - 1749 ( 12 )

Abstract:


MicroRNAs (miRNAs) are non-coding RNAs containing around 22 nucleotides, which are expressed in vertebrates and plants. They act as posttranscriptional gene expression regulators, fine-tuning various biological processes in different cell types. There is emerging evidence on their role in different stages of atherosclerosis. In addition to regulating the inflammatory cells involved in atherosclerosis, miRNAs play fundamental roles in the pathophysiology of atherosclerosis, such as endothelial cell (EC) dysfunction, the aberrant function of the vascular smooth muscle cell (VSMC) and cholesterol metabolism. Moreover, miRNAs participate in several pathogenic pathways of atherosclerotic plaque development, including their effects on immune cell signaling receptors and lipid uptake. In this study, we review our current knowledge of the regulatory role of miRNAs in various pathogenic pathways underlying atherosclerosis development and also outline potential clinical applications of miRNAs in atherosclerosis.

Keywords:

MicroRNA, Atherosclerosis, Inflammation, Clinical application, Immune cells, endothelial cell (EC).

Affiliation:

Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad

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