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Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes

[ Vol. 22 , Issue. 9 ]

Author(s):

Firas Baidoun, Kholoud Elshiwy, Yasmine Elkeraie, Zahi Merjaneh, George Khoudari, Muhammad Talal Sarmini, Mohamed Gad, Muneer Al-Husseini and Anas Saad*   Pages 998 - 1009 ( 12 )

Abstract:


Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer related deaths in the world with an estimated number of 1.8 million new cases and about 881,000 deaths worldwide in 2018. The epidemiology of CRC varies significantly between different regions in the world as well as between different age, gender and racial groups. Multiple factors are involved in this variation, including risk factor exposure, demographic variations in addition to genetic susceptibility and genetic mutations and their effect on the prognosis and treatment response. In this mini-review, we discuss the recent epidemiological trend including the incidence and mortality of colorectal cancer worldwide and the factors affecting these trends.

Keywords:

Colorectal cancer, epidemiology, incidence, mortality, demographic, prognosis.

Affiliation:

Department of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, OH, Faculty of Medicine, Ain Shams University, Cairo, High institute of Public Health, Alexandria University, Alexandria, Department of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, OH, Department of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, OH, Department of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, OH, 4Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, Department of Medicine, Ascension St John Hospital, Detroit, Michigan, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH

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