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Application of Poloxamers for the Development of Drug Delivery System to Treat Leishmaniasis: A Review

[ Vol. 22 , Issue. 3 ]

Author(s):

Audrey Silva, Amanda Costa, Sona Jain, Eduardo Coelho, Ricardo Fujiwara, Ricardo Scher, Rogéria Nunes and Silvio Dolabella*   Pages 296 - 309 ( 14 )

Abstract:


Leishmaniasis is a neglected tropical disease affecting more than 1.5 million people annually, with an annual mortality of over 20.000. The drugs used for its treatment are toxic, expensive, require extended treatment times and present variable efficacy. The disease severity and therapy limitations suggest the need for new antileishmanial agents. In this context, in order to identify new options for treatment, a number of studies based on nanotechnological strategies have been carried out. Poloxamers are triblock copolymers very often utilized for nanotherapeutic solutions, resulting in products with better solubility, higher stability, superior therapeutic efficacy and less toxicity. This review will discuss the physicochemical properties of the copolymers, as well as describe the use of poloxamers for the development of therapeutic formulations to treat leishmaniasis.

Keywords:

Pluronic, triblock copolymers, nanotechnology, leishmania, treatment, chemotherapy.

Affiliation:

Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, 49100-000, Sergipe, Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, 49100-000, Sergipe, Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes, Aracaju, 49032-490, Sergipe, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, 49100-000, Sergipe, Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, 49100-000, Sergipe, Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão, 49100-000, Sergipe



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