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Design of New Improved Curcumin Derivatives to Multi-targets of Cancer and Inflammation

Author(s):

Veena V*, Harikrishnan A and Sunali Khanna   Pages 1 - 17 ( 17 )

Abstract:


Background: Curcumin, a major active principle of Curcuma longa. There are more than 1700 citations in the Medline reflecting various biological effects of curcumin. Most of these biological activities are associated to the antioxidant, anti-inflammatory and antitumor activity of the molecule. Several reports suggest various targets of natural curcumin that includes growth factors, growth factor receptor, cytokines, enzymes and gene regulators of apoptosis. This review focuses on the improved curcumin derivatives that targets the cancer and inflammation.

Methodology: In this present review, we explored the anticancer drugs with curcumin-based drugs under pre-clinical and clinical studies with critical examination. Based on the strong scientific reports of patentable and non-patented literature survey, we have investigated the mode of the interactions of curcumin-based molecules with the target molecules.

Results: Advanced studies have added new dimensions of molecular response of cancer cells to curcumin at genomic level. However, poor bioavailability of the molecule seems to be the major limitation of the curcumin. Several researchers have involved to improve the curcumin derivatives to overcome this limitation. Sufficient data of clinical trials to various cancers that include multiple myeloma, pancreatic cancer and colon cancer are also discussed.

Conclusion: The detailed analysis of structure activity relationship (SAR) and common synthesis of curcumin-based derivatives are discussed in review. Utilising the predictions of in silico coupled with validation reports of in vitro and in vivo studies have concluded many targets for curcumin. Among them, cancer related inflammation genes regulating curcumin-based molecules are very promising target to overcome hurdle in the multimodality therapy of cancer.

Keywords:

Cancer related inflammations, drug targets, anti-inflammatory, anticancer activity, curcumin derivatives.

Affiliation:

Department of Biotechnology, School of Applied Sciences, REVA University, Rukmini knowledge park, Kattigenahalli, Yelahanka, Bengaluru – 5600 064. Karnataka State, Nair Hospital Dental College, Municipal Corporation of Greater Mumbai, Mumbai, 400 008, Department of Chemistry, School of Arts and Sciences, Vinayaka Mission Research Foundation-Aarupadai Veedu (VMRF-AV) campus, Paiyanoor, Chennai-603104, Tamil Nadu



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