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Precision Medicine in the Renin-Angiotensin System: Therapeutic Targets and Biological Variability

Author(s):

Guillermo Alberto Keller*, Maria Laura Ferreiros-Gago, Hector Di-Salvo and Guillermo Di Girolamo   Pages 1 - 13 ( 13 )

Abstract:


Pathologies linked to the renin angiotensin system are frequent, and the drugs used in them are numerous and show great variability in therapeutic effects and adverse reactions. Genetic variants have been detected in the angiotensinogen gene (6), angiotensin converting enzyme (9), Angiotensin converting enzyme 2 (1), and angiotensin receptor Type 1 (4) among others. However, the large number of studies that have analyzed each of them makes it complex and almost impossible to consider all the existing information. This manuscript aims to review the effects of the different known variants on the expected response of different drugs as a basis for the future development of therapeutic guidelines that seek to implement therapeutic individualization strategies on the renin angiotensin system.

Keywords:

Precision medicine, renin-angiotensin-aldosterone system, aldosterone, population biological variations.

Affiliation:

Universidad de Buenos Aires, Facultad de Medicina, Centro de Vigilancia y Seguridad de Medicamentos, Buenos Aires, Universidad de Buenos Aires, Facultad de Medicina, Centro de Vigilancia y Seguridad de Medicamentos, Buenos Aires, Hospital General de Agudos DonaciĆ³n Francisco J. Santojanni, Emergency Department, Buenos Aires, Universidad de Buenos Aires, Facultad de Medicina, Centro de Vigilancia y Seguridad de Medicamentos, Buenos Aires



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