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Past and Present Behçet’s Disease Animal Models

Author(s):

Jermilia Charles, Francis J. Castellino and Victoria A. Ploplis*   Pages 1 - 12 ( 12 )

Abstract:


Behçet’s disease (BD) is presumably an autoinflammatory disease of unknown etiology for which several animal models have been described over the years. Agents and methods used for the development of these models have ranged from the use of transgenic mice, exploring a possible genetic component, to the herpes simplex virus type 1 (HSV-1) pathogen, examining a pathogenic component. Other models have also been used to investigate a possible autoimmune component. Each model possesses its own unique set of benefits and shortcomings, with no one model fully being able to recapitulate the disease phenotype. Here we review proposed models and provide commentary on their effectiveness and usefulness in studying the disease.

Keywords:

Behçet's disease (BD), rare disease, Behçet's Disease Animal Models, autoimmune disease, herpes simplex virus type, human leukocyte antigen

Affiliation:

W.M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, W.M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, W.M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556



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