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Do Drugs Work for ΟΑΒ Following Prostate Cancer Surgery

Author(s):

Vasileios Sakalis * and Anastasia Gkotsi   Pages 1 - 12 ( 12 )

Abstract:


There is evidence that post-radical prostatectomy (post-RP) incontinence is not just insufficiency of external urethral sphincter mechanism. Up to a third of men with post-RP incontinence, suffer from bladder dysfunction, namely overactive bladder (OAB). OAB is complex symptom syndrome with poorly defined pathophysiology. It causes significant burden to patients, negatively affects quality of life and its management might be difficult and challenging. The incidence of post-RP OAB ranges from 15.2 to 37.8%. The aetiology is multifactorial and includes the iatrogenic decentralization of the bladder, the detrusor underactivity, the bladder outlet obstruction and the co-existence with SUI. PostRP SUI may lead to defunctionalized bladder and to activation of urethrovesical reflex which further deteriorate post-RP continence. The diagnostic work of men with post-RP OAB should aim to identify potential aetiologic factors and personalize the treatment accordingly. Up to date there is no robust data from literature with regards to post-RP OAB management. It seems that anticholinergics and PDE5 inhibitors are effective in improving OAB parameters.

Keywords:

Overactive bladder, urge incontinence, radical prostatectomy, prostate cancer, urgency, mixed incontinence

Affiliation:

Agios Pavlos, General Hospital of Thessaloniki, Urology, Agios Pavlos, General Hospital of Thessaloniki, Urology



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