Submit Manuscript  

Article Details


Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article

Author(s):

Sina M. Matalqah, Khalid Aiedeh, Nizar M. Mhaidat, Karem H. Alzoubi*, Yasser Bustanji and Islam Hamad   Pages 1 - 12 ( 12 )

Abstract:


Natural polymers, particularly polysaccharide, have been used as drug delivery systems for a variety of therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and non-parenteral administration. Chitosan, the second most abundant naturally occurring polysaccharide after cellulose, is a biocompatible and biodegradable mucoadhesive polymer that is extensively used in preparation of nanoparticles (NPs). Chitosan NPs loaded with drugs were found to be stable, permeable and bioactive. In this review, the importance of chitosan and its derivatives in drug delivery are illustrated, different methods of preparation of chitosan and chitosan derivatives NPs and their physio-chemical properties are addressed. Moreover, the desirable characteristics for successful NPs based drug delivery systems as well as the pharmaceutical applications of these NPs are also clearly explored.

Keywords:

Chitosan, drug delivery, ionic gelation, emulsification, desolvation, nanoparticles

Affiliation:

Department of Pharmaceutical Science, Faculty of Pharmacy, The University of Jordan, Amman, Department of Pharmaceutical Science, Faculty of Pharmacy, The University of Jordan, Amman, Department of clinical pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Department of clinical pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Department of Biopharmaceutical and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Department of Pharmacy, American University of Madaba, Madaba



Read Full-Text article