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Nanomedicine in Pancreatic Cancer: A New Hope for Treatment

Author(s):

Pablo Redruello, Gloria Perazzoli, Ana Cepero, Francisco Quiñonero, Cristina Mesas, Kevin Doello, Antonio Láinez-Ramos-Bossini, Mario Rivera-Izquierdo, Consolación Melguizo* and Jose Prados   Pages 1 - 13 ( 13 )

Abstract:


Pancreatic ductal adenocarcinoma (PDA) has one of the worse prognosis and higher mortality among most cancers. The diagnosis of PDA is frequently delayed due to a lack of specific biomarkers, and the efficacy of current chemotherapeutic drugs is limited. Moreover, chemotherapy is generally applied in advanced stages, where metastatic spread has already occurred. Nanotechnology-based systems are allowing to advance in the diagnosis and treatment of PDA. New nanoformulations have been shown to improve the activity of conventional chemotherapeutic agents, such as gemcitabine, and new antitumor drugs, protecting them from degradation, improving their selectivity, solubility and bioavailability, and reducing their side effects. Moreover, the design of nanocarriers represents a new way to overcome drug resistance, which requires a comprehensive understanding of the tumor microenvironment of PDA. This article reviews the current perspectives based on nanomedicine to address the limitations of pancreatic cancer treatment, and the futures lines of research to progress in the control of this disease.

Keywords:

Pancreatic ductal adenocarcinoma, chemotherapeutic drugs, nanoparticles, drug resistance, clinical trials

Affiliation:

Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Department of Radiology, Virgen de las Nieves, Hospital, 18012 Granada, Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada



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