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Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications

[ Vol. 22 , Issue. 8 ]

Author(s):

Dickson P. Wande, Qin Cui, Shijie Chen, Cheng Xu, Hui Xiong* and Jing Yao*   Pages 856 - 869 ( 14 )

Abstract:


A unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (To-cophersolan), is a polymeric, synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan allow it to play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability to promote drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor, and anti-cancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavail-ability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as the US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, the current advances in nano-based delivery systems consisting of Tocophersolan, with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostics, were sys-tematically curated.

Keywords:

Tocophersolan, bioavailability, bio-enhancer, drug delivery, nanoparticles, nanotheranostics.

Affiliation:

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, De-partment of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, De-partment of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, De-partment of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, De-partment of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, De-partment of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drugability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009



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