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Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications

Author(s):

Dickson Pius Wande, Qin Cui, Shijie Chen, Cheng Xu, Hui Xiong and Jing Yao*   Pages 1 - 14 ( 14 )

Abstract:


As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

Keywords:

Tocophersolan, bioavailability, bio-enhancer, drug delivery, nanoparticles, nanotheranostic

Affiliation:

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drugability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drugability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drugability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drugability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drugability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drugability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009



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