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Does Pharmacodynamics of Drugs Change After Presenting them as Nanoparticles Like their Pharmacokinetics?

[ Vol. 21 , Issue. 8 ]

Author(s):

Razieh Mohammad Jafari, Moein Ala, Navid Goodarzi and Ahmad Reza Dehpour*   Pages 807 - 818 ( 12 )

Abstract:


Nowadays, the breakthrough in different medical branches makes it feasible to designate new methods of drug delivery to achieve the most cost-effective and the least unpleasant consequenceimposing solutions to overcome a wide range of diseases.

Nanoparticle (NP) drugs entered the therapeutic system, especially in cancer chemotherapy. These drugs are quite well-known for two traits of being long-acting and less toxic. For a long time, it has been investigated how NPs will change the kinetics of drugs. However, there are a few studies that inclined their attention to how NPs affect the dynamics of drugs. In this review, the latter point will mainly be discussed in an example-based manner. Besides, other particular features of NPs will be briefly noted.

NPs are capable of affecting the biologic system as much as a drug. Moreover, NPs could arise a wide variety of effects by triggering their own receptors. NPs are able to change a receptor function and manipulate its downstream signaling cascade.

Keywords:

Nanoparticles, pharmacodynamics, post receptor effects, drug-receptor interaction, drug delivery, kinetics of drugs.

Affiliation:

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran



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