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Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin

[ Vol. 21 , Issue. 5 ]

Author(s):

Rémi Safi, Marwan El-Sabban and Fadia Najjar*   Pages 499 - 508 ( 10 )

Abstract:


Ferula hermonis Boiss, is an endemic plant of Lebanon, locally known as “shilsh Elzallouh”. It has been extensively used in the traditional medicine as an aphrodisiac and for the treatment of sexual impotence. Crude extracts and isolated compounds of ferula hermonis contain phytoestrogenic substances having a wide spectrum of in vitro and in vivo pharmacological properties including anti-osteoporosis, anti-inflammatory, anti-microbial and anti-fungal, anti-cancer and as sexual activity enhancer. The aim of this mini-review is to highlight the traditional and novel applications of this plant’s extracts and its major sesquiterpene ester, ferutinin. The phytochemical constituents and the pharmacological uses of ferula hermonis crude extract and ferutinin specifically will be discussed.

Keywords:

Ferula hermonis, ferutinin, crude extract, pharmacological properties, phytochemical constituents, phytoestrogenic.

Affiliation:

Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Department of Chemistry and Biochemistry, Laboratoire d’Innovation Thérapeutique, Faculty of Sciences II, Lebanese University



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