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Combining Radiotherapy with Immunocheckpoint Inhibitors or CAR-T in Renal Cell Carcinoma

[ Vol. 21 , Issue. 4 ]

Author(s):

Matteo Santoni, Daniel Y.C. Heng, Gaetano Aurilio, Andrea Iozzelli, Lucilla Servi, Andrea Fabiani, Massimo Giannini, Roberta Mazzucchelli, Alessia Cimadamore, Marina Scarpelli, Mohamed S. Zaghloul, Nicola Battelli and Rodolfo Montironi*   Pages 416 - 423 ( 8 )

Abstract:


Radiotherapy is considered a second life in Renal Cell Carcinoma (RCC) patients, mainly due to the introduction of immune checkpoint inhibitors, such as anti-Programmed-death (PD)-1, alone or in combination with anti-Cytotoxic T-Lymphocyte Antigen (CTLA)-4. Several trials are investigating the efficacy/safety of immune checkpoint inhibitors in sequential or combined strategies with radiotherapy. Chimeric Antigen Receptor (CAR)-T cells therapy as a promising approach in cancer patients has opened the way to novel possibilities of integrating therapies. The identification of biomarkers of tumor response to these combinations represents a challenge in RCC, together with the research for the best partner for immunotherapy in metastatic patients. In this review we illustrated preclinical/clinical data on the integration of radiotherapy with immunocheckpoint inhibitors or CART cells in RCC.

Keywords:

CAR-T cells, immunocheckpoint inhibitors, immunotherapy, programmed-death-1, radiation therapy, renal cell carcinoma.

Affiliation:

Oncology Unit, Macerata Hospital, via Santa Lucia 2, Macerata, Department of Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, AB, IEO, European Institute of Oncology IRCCS, Medical Division of Urogenital and Head & Neck Cancer, Milan, Radiology Unit, Macerata Hospital, via Santa Lucia 2, Macerata, Urology Unit, Macerata Hospital, Via Santa Lucia 2, Macerata, Urology Unit, Macerata Hospital, Via Santa Lucia 2, Macerata, UOC Radioterapia Oncologica, Macerata Hospital, via Santa Lucia 2, Macerata, Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Radiotherapy Department, National Cancer Institute, Cairo University & Children's Cancer Hospital Egypt (CCHE), Cairo, Oncology Unit, Macerata Hospital, via Santa Lucia 2, Macerata, Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona

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