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Study of Monocytes/Macrophages Stimuli as the Targets of Treating Inflammatory Bone Diseases

[ Vol. 21 , Issue. 4 ]

Author(s):

Yuan Liu, Yang Cao, Wanli Smith, Baorong He and Liang Yan*   Pages 338 - 343 ( 6 )

Abstract:


Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different cell models could regulate this progress in some aspects. Therefore, in the current review, we summarize several cytokines and cell models, which could lead to inflammatory orthopedic diseases via regulating monocytes and macrophages. In order to extensively explore the potential therapeutic and medicine targets for inflammation-induced bone diseases.

Keywords:

Macrophages, cytokines, rheumatoid arthritis, osteoarthritis, osteolysis, monocyte.

Affiliation:

Department of Orthopedics, Honghui-hospital, Xi’an Jiaotong University, School of medicine, Xi’an, Department of Orthopedics, Honghui-hospital, Xi’an Jiaotong University, School of medicine, Xi’an, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, 600 N. Wolfe St. Baltimore, Maryland, Department of Orthopedics, Honghui-hospital, Xi’an Jiaotong University, School of medicine, Xi’an, Department of Orthopedics, Honghui-hospital, Xi’an Jiaotong University, School of medicine, Xi’an

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