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Trans-sialidase Associated with Atherosclerosis: Defining the Identity of a Key Enzyme Involved in the Pathology

Author(s):

Victor Yu. Glanz, Veronika A. Myasoedova, Andrey V. Grechko and Alexander N. Orekhov*   Pages 1 - 4 ( 4 )

Abstract:


Atherosclerosis is associated with increased trans-sialidase activity, which can be detected in atherosclerosis patients’ blood plasma. The likely involvement in the disease pathogenesis made this activity an interesting research subject, and the enzyme that may performs such activity had been isolated and characterized in terms of substrate specificity and enzymatic properties. It was found that the enzyme had distinct optimum pH values, and its activity was enhanced by the presence of Ca2+ ions. Most importantly, the enzyme was able to cause atherogenic modification of low-density lipoprotein (LDL) particles in vitro. However, the identity of the discovered enzyme remained to be defined. Currently, sialyltransferases, mainly ST6Gal I, are regarded as major contributors to sialic acid metabolism in human blood. In this mini review, we discuss the possibility that atherosclerosis-associated trans-sialidase does in fact belong to the sialyltransferases family.

Keywords:

trans-sialidase , sialic acid , sialyltransferase , atherosclerosis , blood plasma , circulation

Affiliation:

Department of Genetics, Cytology and Bioengineering, Faculty of Biology and Medicine, Voronezh State University, Voronezh, Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 109240 Moscow, Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow



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