Fazlurrahman Khan, Aqib Javaid and Young-Mog Kim* Pages 1 - 14 ( 14 )
Biofilm formation by pathogenic bacteria is considered as one of the most powerful mechanisms/ modes of resistance against the action of several antibiotics. Biofilm is formed as a structural adherent over the surfaces of host, food and equipments etc. and are further functionally coordinated by certain chemicals produced by them. These chemicals are known as quorum sensing (QS) signaling molecules and are involved in the cross talk at inter species, intra-species and interkingdom levels that results in the production of virulence factors involved in the pathogenesis. Bacteria possess receptor to sense these chemicals, which interact with the incoming QS molecules. It is followed by the secretion of virulence molecules, regulation of bioluminescence, biofilm formation, antibiotic resistance development and motility behavioral responses. In the natural environment different bacterial species (Gram-positive and Gram-negative), produce QS signaling molecules that are structurally and functionally different. Recent and past researches show that various antagonistic molecules (naturally and chemically synthesized) have been characterized to inhibit biofilm formation and attenuation of bacterial virulence by blocking the QS receptors. This review article describes about the diverse QS receptors at their structural, functional and production levels. Thus by blocking these receptors with inhibitory molecules can be potential therapeutic approach to control pathogenesis. Furthermore, these receptors can also be used as structural platform to screen the most potent inhibitors with the help bioinformatics approaches.
Bacteria, Inhibitor, Pathogenesis, Quorum sensing receptor
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida-201306, U.P., Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida-201306, U.P., Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513