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Three-Dimensional Manufactured Supports for Breast Cancer Stem Cell Population Characterization

Author(s):

Emma Polonio-Alcalá, Marc Rabionet, Santiago Ruiz-Martínez, Joaquim Ciurana* and Teresa Puig*   Pages 1 - 13 ( 13 )

Abstract:


Breast Cancer (BC) is the most common cancer among women and the second cause of female death for cancer. When the tumor is not correctly eradicated, there is a high relapse risk and incidence of metastasis. Breast Cancer Stem Cells (BCSCs) are responsible for initiating tumors and are resistant to current anticancer therapies being in part responsible for tumor relapse and metastasis. The study of BCSCs is limited due to their low percentage within both tumors and established cell models. Hence, three-dimensional (3D) supports are presented as an interesting tool to keep the stem-like features in 3D cell culture. In this review, several 3D culture systems are discussed. Moreover, scaffolds are presented as a tool to enrich in BCSCs in order to find new specific therapeutic strategies against this malignant subpopulation. Anticancer treatments focused on BCSCs being useful for BC patients, with particular interest in those that progress to current therapies.

Keywords:

triple negative breast cancer, cancer stem cells, breast cancer stem cells biomarkers, three-dimensional cell culture, scaffolds, electrospinning, fused filament fabrication, additive manufacturing

Affiliation:

New Therapeutic Targets Laboratory (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, New Therapeutic Targets Laboratory (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, New Therapeutic Targets Laboratory (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Product, Process and Production Engineering Research Group (GREP), Department of Mechanical Engineering and Industrial Construction, University of Girona, Girona, New Therapeutic Targets Laboratory (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona



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