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CDK9 as an Appealing Target for Therapeutic Interventions

[ Vol. 20 , Issue. 4 ]

Author(s):

Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*   Pages 453 - 464 ( 12 )

Abstract:


Cyclin Dependent Kinase 9 (CDK9) as a serine/threonine kinase belongs to a great number of CDKs. CDK9 is the main core of PTEF-b complex and phosphorylates RNA polymerase (RNAP) II besides other transcription factors which regulate gene transcription elongation in numerous physiological processes. Multi-functional nature of CDK9 in diverse cellular pathways proposes that it is as an appealing target. In this review, we summarized the recent findings on the molecular interaction of CDK9 with critical participant molecules to modulate their activity in various diseases. Furthermore, the presented review provides a rationale supporting the use of CDK9 as a therapeutic target in clinical developments for crucial diseases; particularly cancers will be reviewed.

Keywords:

CDK9, cardiac pathway, cancer, viral agents, fibrosis, inflammation, RNAP.

Affiliation:

Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz

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