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Drosophila Renal Organ as a Model for Identification of Targets and Screening of Potential Therapeutic Agents for Diabetic Nephropathy

[ Vol. 19 , Issue. 16 ]

Author(s):

Lavi Rani and Naveen Kumar Gautam*   Pages 1980 - 1990 ( 11 )

Abstract:


Diabetic nephropathy is one of the major causes of kidney failure, accounting for ~44% of all cases. In spite of the significant mortality rate of diabetic nephropathy, specific and effective treatment is still eluding. Identification of genetic determinants and understanding their role in the progression of disease are essential for developing diagnostic tools and effective therapy. Drosophila melanogaster is a genetically tractable model organism and is being used for understanding the genetic basis of several human diseases. Drosophila has a well developed renal system and shares conserved developmental and functional processes with humans. Apart from similarities in renal system, type 1 and type 2 diabetes can be induced in Drosophila following mechanisms similar to those in human. This review discusses the current therapies available for diabetic nephropathy and examines the potential of Drosophila renal system as a model for identifying drug targets for diabetic nephropathy and screening of the potential drugs for their efficacy.

Keywords:

Diabetic nephropathy, Drosophila melanogaster, podocytes, nephrocytes, Drosophila renal organ, therapeutic agents.

Affiliation:

Embryotoxicology Laboratory, Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIRIITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow- 226001, Uttar Pradesh, Embryotoxicology Laboratory, Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIRIITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow- 226001, Uttar Pradesh

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