Sounik Manna, Munmun Ghosh, Ranadhir Chakraborty, Sudipto Ghosh and Santi M. Mandal* Pages 255 - 262 ( 8 )
Succumbing to Multi-Drug Resistant (MDR) bacteria is a great distress to the recent health care system. Out of the several attempts that have been made to kill MDR pathogens, a few gained short-lived success. The failures, of the discovered or innovated antimicrobials, were mostly due to their high level of toxicity to hosts and the phenomenal rate of developing resistance by the pathogens against the new arsenal. Recently, a few quantum dots were tested against the pathogenic bacteria and therefore, justified for potential stockpiling of next-generation antibacterial agents. The key players for antimicrobial properties of quantum dots are considered to be Reactive Oxygen Species (ROS). The mechanism of reaction between bacteria and quantum dots needs to be better understood. They are generally targeted towards the cell wall and membrane components as lipoteichoic acid and phosphatidyl glycerol of bacteria have been documented here. In this paper, we have attempted to simulate ZnS quantum dots and have analysed their mechanism of reaction as well as binding potential to the above bacterial membrane components using CDOCKER. Results have shown a high level of antibacterial activity towards several pathogenic bacteria which specify their potentiality for future generation antibacterial drug development.
Antibacterial agent, lipoteichoic acid, phosphatidylglycerol, quantum dots, CDOCKER, Multi-Drug Resistant (MDR).
Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, OMICS Laboratory, Department of Biotechnology, University of North Bengal, Siliguri 734013, WB, Department of Metallurgical and Materials Engineering, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB