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Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes

[ Vol. 19 , Issue. 13 ]

Author(s):

Caroline Floreoto Baldo, Luiza Mateus Silva, Livia Arcencio, Agnes Afrodite Sumarelli Albuquerque, Andrea Carla Celotto, Anibal Basile-Filho and Paulo Roberto B Evora*   Pages 1560 - 1569 ( 10 )

Abstract:


Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.

Keywords:

Methylene blue, cGMP, nitric oxide, circulatory shock, neuroprotection, anaphylaxis, poisoning.

Affiliation:

Anesthesia and Pain Medicine Veterinary Medical Center College of Veterinary Medicine University of Minnesota, MN, Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP, Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP, Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP, Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP, Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP, Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP



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