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Therapeutic Applications of Liposomal Based Drug Delivery and Drug Targeting for Immune Linked Inflammatory Maladies: A Contemporary View Point

[ Vol. 18 , Issue. 13 ]

Author(s):

Mahfoozur Rahman *, Sarwar Beg , Amita Verma, Imran Kazmi, Dinesh Kumar Patel , Firoz Anwar , Fahad A Al Abbasi and Vikas Kumar *   Pages 1558 - 1571 ( 14 )

Abstract:


Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in inflammatory cytokines cells and several genes. The available drug therapy provides suboptimal therapeutic effects and higher adverse effects. Emergence of liposomal systems of the drugs meant for the above mentioned disease has gained broader importance due to their high treatment efficacy by means of optimal therapeutic drug delivery. Beyond the conventional liposomal formulations, evolution of second generation liposomes including stealth liposomes, cationic liposomes, immuno-liposomes, etc. has gained tremendous attention owing to their drug target potential, diagnostic importance and imaging in treatment of above mentioned immune mediated inflammatory disorders.

Keywords:

Immune mediated inflammatory disorders, liposomes, cationic liposomes, immuno-liposomes, atherosclerosis, multiple sclerosis.

Affiliation:

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh, Bioorganic and medicinal chemistry research laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, School of Pharmacy, Glocal University, Saharanpur, U.P, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad

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