Guilong Zhang, Ahsan Ali Khan, Hao Wu, Lukui Chen*, Yuchun Gu and Ning Gu Pages 279 - 298 ( 20 )
Background: Stem cell therapy provides great promising therapeutic benefits for various neurological disorders. Cell transplantation has emerged as cell replacement application for nerve damage. Recently, nanomaterials obtain wide development in various industrial and medical fields, and nanoparticles have been applied in the neurological field for tracking and treating nervous system diseases. Combining stem cells with nanotechnology has raised more and more attentions; and it has demonstrated that the combination has huge effects on clinical diagnosis and therapeutics in multiple central nervous system diseases, meanwhile, improves prognosis.
Objective: The aim of this review was to give a brief overview of the application of nanomaterials in stem cell therapy for neurological diseases.
Results: Nanoparticles not only promote stem cell proliferation and differentiation in vitro or in vivo, but also play dominant roles on stem cell imaging and tracking. Furthermore, via delivering genes or drugs, nanoparticles can participate in stem cell therapeutic applications for various neurological diseases, such as ischemic stroke, spinal cord injury (SCI), multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD) and gliomas. However, nanoparticles have potential cytotoxic effects on nerve cells, which are related to their physicochemical properties.
Conclusion: Nano-stem cell-based therapy as a promising strategy has the ability to affect neuronal repair and regeneration in the central nervous system.
Stem cell, nanoparticles, CNS diseases, neurogenesis, tracking, cell transplantation.
Department of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Department of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, Department of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Aston Institute of Regenerative Medicine, Aston Medical School, Aston University, Birmingham, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009