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Neuroprotective Effects of Ellagitannins: A Brief Review

[ Vol. 18 , Issue. 13 ]


Silvia Tejada, William N. Setzer, Maria Daglia, Seyed Fazel Nabavi, Antoni Sureda, Nady Braidy, Olga Gortzi and Seyed Mohammad Nabavi*   Pages 1518 - 1528 ( 11 )


Background: Neurodegenerative diseases are increasingly inevitable as the population gets older, with enormous socio-economic costs. The World Health Organization (WHO) has reported that by 2040, neurodegenerative diseases will overtake cancer to become the second leading cause of death, after cardiovascular disease.

Objective: Herein, this review outlines the neuroprotective effects and clinical implications of ellagitannins, a class of hydrolysable tannins, for the management and treatment of neurodegenerative disorders.

Results: Recent investigations suggest that the combination of genes and environmental toxins may contribute to the risk of developing neurodegenerative disorders. Thus, intervention strategies aimed at reducing exposure to risk factors such as life style, smoking, diet, vitamin deficiencies, chemical exposure and pollution are warranted. Modulation of dietary components including ellagitannins, as a therapeutic strategy to slow down or attenuate the progression of neuronal degeneration has become a focus of interest in the last few decades.

Conclusion: Polyphenolic plant phytochemicals and ellagitannins in particular, contain an array of neuroprotective properties useful to improve human health and protect against neurodegeneration.


Antioxidant, ellagitannins, neurodegenerative, mental diseases, polyphenolic.


Experimental Laboratory, Research Unit, Son Llàtzer Hospital, IUNICS, Ctra. Manacor km 4, E-07198, Palma de Mallorca, Balearic Islands, Department of Chemistry, University of Alabama in Huntsville, Alabama 35899, Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Research Group on Community Nutrition and Oxidative Stress (NUCOX) and CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), University of Balearic Islands, Palma de Mallorca E-07122, Balearic Islands, Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Department of Food Technology, Technological Educational Institution of Thessaly Terma N. Temponera Str, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487

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