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Functionalized Magnetic Nanostructures for Anticancer Therapy

[ Vol. 19 , Issue. 3 ]

Author(s):

Eugenia Dumitra Teodor*, Florentina Gatea, Anton Ficai and Gabriel Lucian Radu   Pages 239 - 247 ( 9 )

Abstract:


Background: In the last years, the production and applications of nanoparticles based on iron oxides in the field of biomedicine presented a great interest due to their particular properties. Because of the expansion of the pharmaceutical industry numerous new systems for drugs delivery have appeared, and those centered on magnetic nanoparticles are in a particular attention and in different promising developmental stages.

Objective: In this mini review, some representative, interesting and feasible magnetic nanostructures obtained recently (from last 5-6 years) with possible use in antitumor/anticancer therapy are presented.

Results: The synthesis of these nanostructures with magnetic properties implies very simple assembling procedures and presents one of the lowest cytotoxic profiles. Magnetic nanostructures displayed possible appliance in a large diversity of biotechnological and medical fields, both for diagnose and therapy.

Conclusion: Different types of magnetic nano-carriers loaded with different antitumor/anticancer agents and the cases tested in vivo are considered.

Keywords:

Functionalized magnetic nanostructures, anticancer therapy, drug delivery, combined drug release, imaging and hyperthermia.

Affiliation:

Centre of Bioanalysis, National Institute for Biological Sciences, Bucharest, Centre of Bioanalysis, National Institute for Biological Sciences, Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Bucharest, Department of Analytical Chemistry and Instrumental Analysis, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest

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