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Proteinase Inhibitors: A Promising Drug Class for Treating Leishmaniasis

[ Vol. 15 , Issue. 12 ]

Author(s):

Bernardo Acacio Santini Pereira, Franklin Souza-Silva, Mariana Silva-Almeida, Raquel Santos-de-Souza, Luiz Filipe Goncalves de Oliveira, Michelle Lopes Ribeiro-Guimaraes and Carlos Roberto Alves   Pages 1121 - 1131 ( 11 )

Abstract:


This review presents and discusses the current status and perspectives of leishmaniasis treatment, with a special focus on the use of proteinase inhibitors. The history of treatment development, the first- and second-choice modern drugs and the advantages and disadvantages of using proteinases inhibitors as leishmanicidal treatments are presented and discussed. The reports gathered herein confirm the potential usefulness of proteinases inhibitors as an alternative or complement to the current leishmaniasis treatments. They also support the hypothesis that a combined treatment with multiple proteinase inhibitors may be efficient against Leishmania infections in vertebrate hosts.

Keywords:

Leishmaniasis, Leishmania, proteinases, proteinase inhibitors, treatment, virulence factors.

Affiliation:

Laboratorio de Biologia Molecular e Doenças Endemicas, Instituto Oswaldo Cruz - Fiocruz, Avenida Brasil, 4365 Pavilhao Leonidas Deane, sala 209A, Manguinhos, Rio de Janeiro, RJ - CEP: 21040-900, Brasil.



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